2369030-41-9

2369030-41-9 structure

Name: ROS-generating agent 1
Chemical Name: ROS-generating agent 1
CAS Number: 2369030-41-9
Molecular Formula: C₂₁H₁₅F₆NO
Molecular Weight: 411.34
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-09-18 20:51:17
Modify Date: 2024-01-02 20:48:49
ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities[1].

Name	ROS-generating agent 1

Description	ROS-generating agent 1 (Compound 2c) covalently modifies the Sec-498 residue of TrxR to generate ROS. ROS-generating agent 1 reduces intracellular TrxR protein level. ROS-generating agent 1 results in ROS-dependent apoptosis and ferroptosis of NCI-H460 cells. ROS-generating agent 1 has anti-cancer activities[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Ferroptosis
References	[1]. Liu X, et al. Tumor killing by a dietary curcumin mono-carbonyl analog that works as a selective ROS generator via TrxR inhibition. Eur J Med Chem. 2023 Mar 15;250:115191.

Molecular Formula	C₂₁H₁₅F₆NO
Molecular Weight	411.34