PROTAC IRAK4 degrader-1
Modify Date: 2025-08-20 20:37:44
PROTAC IRAK4 degrader-1 structure
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Common Name | PROTAC IRAK4 degrader-1 | ||
|---|---|---|---|---|
| CAS Number | 2360533-90-8 | Molecular Weight | 904.85 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C44H39F3N12O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC IRAK4 degrader-1PROTAC IRAK4 degrader-1 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively[1]. |
| Name | PROTAC IRAK4 degrader-1 |
|---|
| Description | PROTAC IRAK4 degrader-1 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively[1]. |
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| Related Catalog | |
| Target |
IRAK4 Cereblon |
| References |
[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1. |
| Molecular Formula | C44H39F3N12O7 |
|---|---|
| Molecular Weight | 904.85 |
| InChIKey | YXSXFMHKDNIZFS-UHFFFAOYSA-N |
| SMILES | O=C1CCC(N2C(=O)c3cccc(NCc4cn(CCCNC(=O)c5ccc(-n6cc(NC(=O)c7coc(-c8ccnc(NCC9CC9)c8)n7)c(C(F)(F)F)n6)cc5)cn4)c3C2=O)C(=O)N1 |
| Storage condition | -20°C |