Shikalkin

Modify Date: 2024-01-02 22:18:35

Shikalkin structure	Common Name	Shikalkin
	CAS Number	23444-65-7	Molecular Weight	288.295
	Density	1.4±0.1 g/cm3	Boiling Point	567.4±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₆O₅	Melting Point	149°C
	MSDS	Chinese	Flash Point	311.0±26.6 °C

Use of Shikalkin

Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent[1].

Name	alkannin
Synonym	More Synonyms

Description	Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Ras
In Vitro	Alkannin is a potent and specific inhibitor to PKM2, an enzyme that dictates the last rate-limiting step of glycolysis, which is essential for cancer cells’ proliferation and survival. In the absence of D-fructose-1,6-bisphosphate (FBP), the IC50 of Alkannin is 0.3 μM. In the presence of FBP (125 μM), the IC50 of Alkannin is 0.9 μM, respectively. Alkannin effectively inhibits the cellular glycolytic flux in cancer cells dominantly expressing PKM2[1]. Alkannin (2.5-20 μM, 1 hour) inhibit the rates of cellular lactate production and glucose consumption[1]. Western Blot Analysis[1] Cell Line: MCF-7 and A549 express PKM2 but not PKM1 and PKL Concentration: 0-20 μM Incubation Time: 1 hour Result: Inhibited the cellular glycolytic rate in a concentration-dependent manner.
References	[1]. J Chen, et al. Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2. Oncogene. 2011 Oct 20;30(42):4297-306.

Density	1.4±0.1 g/cm3
Boiling Point	567.4±50.0 °C at 760 mmHg
Melting Point	149°C
Molecular Formula	C₁₆H₁₆O₅
Molecular Weight	288.295
Flash Point	311.0±26.6 °C
Exact Mass	288.099762
PSA	94.83000
LogP	4.35
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.642

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL8000000

CHEMICAL NAME :: 1,4-Naphthoquinone, 5,8-dihydroxy-6-(1-hydroxy-4-methyl-3-pentenyl)-, (-)-

CAS REGISTRY NUMBER :: 23444-65-7

BEILSTEIN REFERENCE NO. :: 3213296

LAST UPDATED :: 199801

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H16-O5

MOLECULAR WEIGHT :: 288.32

WISWESSER LINE NOTATION :: L66 BV EVJ CYQ2YU1&1 GQ JQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NAHRAR Nahrung. Chemistry, Biochemistry, Microbiology, Technology, Nutrition. (Akademie-Verlag GmBH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1957- Volume(issue)/page/year: 15,505,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NAHRAR Nahrung. Chemistry, Biochemistry, Microbiology, Technology, Nutrition. (Akademie-Verlag GmBH, Postfach 1233, Berlin DDR-1086, Ger. Dem. Rep.) V.1- 1957- Volume(issue)/page/year: 15,505,1971

Hazard Codes	Xi
Risk Phrases	22
Safety Phrases	22-24/25
HS Code	2914690090

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

SHIKALKIN

5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)-1,4-naphthoquinone

1,4-Naphthalenedione, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-penten-1-yl)-

Arnebin-4

Alkannin

(±)-Alkannin

5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-penten-1-yl)-1,4-naphthoquinone

5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione

DC Chemicals Limited
China
Product Name: Alkannin
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: alkannin
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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