Dimethyl Fumarate-2,3-d2

Modify Date: 2024-01-03 15:19:34

Dimethyl Fumarate-2,3-d2 structure	Common Name	Dimethyl Fumarate-2,3-d2
	CAS Number	23057-98-9	Molecular Weight	146.138
	Density	1.1±0.1 g/cm3	Boiling Point	193.0±0.0 °C at 760 mmHg
	Molecular Formula	C₆H₆D₂O₄	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	91.1±0.0 °C

Use of Dimethyl Fumarate-2,3-d2

Dimethyl fumarate-d2 is the deuterium labeled Dimethyl fumarate[1]. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research[2][3].

Name	dimethyl fumarate-2,3-d2
Synonym	More Synonyms

Description	Dimethyl fumarate-d2 is the deuterium labeled Dimethyl fumarate[1]. Dimethyl fumarate (DMF) is an orally active and brain-penetrant Nrf2 activator and induces upregulation of antioxidant gene expression. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway, and also induces cell autophagy. Dimethyl fumarate can be used for multiple sclerosis research[2][3].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Autophagy >> Autophagy
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Peng H, et al. Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling. J Biol Chem. 2012 Aug 10;287(33):28017-26. [3]. Cross SA, et al. Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. J Immunol. 2011 Nov 15187(10):5015-25. [4]. Jing X, et al. Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinson's disease by enhancing Nrf2 activity. Neuroscience. 2015 Feb 12286:131-40 [5]. Xin Xie, et al. Dimethyl fumarate induces necroptosis in colon cancer cells through GSH depletion/ROS increase/MAPKs activation pathway. Br J Pharmacol. 2015 Aug172(15):3929-43.

Density	1.1±0.1 g/cm3
Boiling Point	193.0±0.0 °C at 760 mmHg
Molecular Formula	C₆H₆D₂O₄
Molecular Weight	146.138
Flash Point	91.1±0.0 °C
Exact Mass	146.054810
PSA	52.60000
LogP	0.62
Vapour Pressure	0.5±0.3 mmHg at 25°C
Index of Refraction	1.435

Hazard Codes	C
Risk Phrases	21-38-41-43
Safety Phrases	26-36/37/39

Precursor 0
DownStream 1
CAS#:24461-32-3 (2E)-(2H2)-2-Bu...

2,3-dideuterio-fumaric acid

Fumaric acid-2,3-d2

2,3-Dideuterio-fumarsaeure-dimethylester

2,3-dideuterio-fumaric acid dimethyl ester

dimethyl fumarate-d2

2,3-2H-fumaric acid

2-Butenedioic-2,3-d acid, dimethyl ester, (2E)-

Dimethyl (2E)-(H)but-2-enedioate

Maleic acid-2,3-d2

Dimethyl (2E)-(H)-2-butenedioate

2,3-Dideuterio-fumarsaeure

Dimethyl Fumarate-2,3-d2

Use of Dimethyl Fumarate-2,3-d2

Names

Dimethyl Fumarate-2,3-d2 Biological Activity

Chemical & Physical Properties

Safety Information

Precursor & DownStream

Synonyms