Antibacterial agent 124

Modify Date: 2025-09-25 14:28:36

Antibacterial agent 124 structure	Common Name	Antibacterial agent 124
	CAS Number	2304448-00-6	Molecular Weight	337.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₇ClFN₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Antibacterial agent 124

Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC50 of 0.18 μM against Staphylococcus aureus ProRS (SaProRS)[1].

Name	Antibacterial agent 124

Description	Antibacterial agent 124 (Compound 3) is a potent bacterial prolyl-tRNA synthetase (ProRS) inhibitor with an IC50 of 0.18 μM against Staphylococcus aureus ProRS (SaProRS)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Target	IC50: 0.18 μM (SaProRS)[1] Kd: 30.3 nM (SaProRS)[1]
In Vitro	Antibacterial agent 124 (Compound 3) shows antibacterial activity with MICs of 1, 1, 4, 1, 1, 2 and 4 μg/mL against E. coli (ATCC25922), S. flexneri (CMCC51572), S. typhi (CMCC50094), MRSA252, MRSA R3708, S. aureus ATCC29213, S. aureus ATCC25923, respectively. And the CC50 to HepG2 is 4.32 μM[1].
References	[1]. Cheng B, et al. Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. J Med Chem. 2022 Nov 17.

Molecular Formula	C₁₆H₁₇ClFN₃O₂
Molecular Weight	337.78

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