QM385

Modify Date: 2025-08-25 11:33:46

QM385 Structure
QM385 structure
Common Name QM385
CAS Number 2296727-52-9 Molecular Weight 408.38
Density N/A Boiling Point N/A
Molecular Formula C18H19F3N6O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of QM385


QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1].

 Names

Name QM385

 QM385 Biological Activity

Description QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1].
Related Catalog
Target

IC50: 1.49 nM (Sepiapterin reductase)[1]

In Vitro QM385 effectively inhibits the proliferation of human CD4+ T cells at low doses[1].
References

[1]. Cronin SJF, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 Nov;563(7732):564-568.

 Chemical & Physical Properties

Molecular Formula C18H19F3N6O2
Molecular Weight 408.38
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