QM385

Names

[ Name ]:
QM385

Biological Activity

[Description]:

QM385 is a potent sepiapterin reductase (SPR) inhibitor with an IC50 of 1.49 nM, which blocks T-cell proliferation and autoimmunity at nanomolar potency and with good oral bioavailability[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Inflammation/Immunology

[Target]

IC50: 1.49 nM (Sepiapterin reductase)[1]

[In Vitro]

QM385 effectively inhibits the proliferation of human CD4+ T cells at low doses[1].

[References]

[1]. Cronin SJF, et al. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 Nov;563(7732):564-568.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₉F₃N₆O₂

[ Molecular Weight ]:
408.38

Related Compounds

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