Oxyclozanide

Modify Date: 2024-01-02 18:24:48

Oxyclozanide structure	Common Name	Oxyclozanide
	CAS Number	2277-92-1	Molecular Weight	401.457
	Density	1.8±0.1 g/cm3	Boiling Point	446.0±45.0 °C at 760 mmHg
	Molecular Formula	C₁₃H₆Cl₅NO₃	Melting Point	205 - 210ºC
	MSDS	Chinese USA	Flash Point	223.5±28.7 °C
	Symbol	GHS07, GHS09	Signal Word	Warning

Use of Oxyclozanide

Oxyclozanide is a salicylanilide anthelmintic drug that mainly acts by uncoupling oxidative phosphorylation in flukes.

Name	Oxyclozanide
Synonym	More Synonyms

Description	Oxyclozanide is a salicylanilide anthelmintic drug that mainly acts by uncoupling oxidative phosphorylation in flukes.
Related Catalog	Signaling Pathways >> Anti-infection >> Parasite Research Areas >> Infection
Target	Parasite[1]
References	[1]. Gokbulut C, et al. Comparative pharmacokinetics of levamisole-oxyclozanide combination in sheep and goats following per os administration. Can J Vet Res. 2014 Oct;78(4):316-20.

Density	1.8±0.1 g/cm3
Boiling Point	446.0±45.0 °C at 760 mmHg
Melting Point	205 - 210ºC
Molecular Formula	C₁₃H₆Cl₅NO₃
Molecular Weight	401.457
Flash Point	223.5±28.7 °C
Exact Mass	398.879028
PSA	69.56000
LogP	8.67
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.722
Storage condition	0-6°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CV8576000

CHEMICAL NAME :: Benzanilide, 2,2'-dihydroxy-3,3',5,5',6-pentachloro-

CAS REGISTRY NUMBER :: 2277-92-1

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C13-H6-Cl5-N-O3

MOLECULAR WEIGHT :: 401.45

WISWESSER LINE NOTATION :: QR BG DG FMVR BQ CG EG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 210,744,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: VETRAX Veterinary Record. (7 Mansfield St., London W1M 0AT, UK) V.1- 1888- Volume(issue)/page/year: 78,267,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - cattle

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation

REFERENCE :: VETRAX Veterinary Record. (7 Mansfield St., London W1M 0AT, UK) V.1- 1888- Volume(issue)/page/year: 78,267,1966

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - domestic

DOSE/DURATION :: 10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VETRAX Veterinary Record. (7 Mansfield St., London W1M 0AT, UK) V.1- 1888- Volume(issue)/page/year: 78,267,1966

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H410
Precautionary Statements	P273-P501
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;N:Dangerousfortheenvironment;
Risk Phrases	R22;R50/53
Safety Phrases	S60-S61
RIDADR	UN 3077
RTECS	CV8576000
HS Code	2924299090

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

[The investigation of short term efficiency of oxfendazole + oxyclozanide paste and tablet formulations against gastrointestinal nematodes in sheep].

Turkiye. Parazitol. Derg. 32(2) , 134-8, (2008)

The aim of this study was to investigate the effectiveness of tablet and paste formulations of Oxfendazole and Oxyclozanide combinations against subclinical gastrointestinal nematode infections and to...

Determination of bithionol, bromophen, nitroxynil, oxyclozanide, and tribromsalan in milk with liquid chromatography coupled with tandem mass spectrometry.

J. AOAC Int. 93(4) , 1340-6, (2010)

LC/MS/MS was developed to determine the residues of bithionol (BTN), bromofen (BMF), nitroxynil (NTX), oxyclozanide (OCZ), and tribromsalan (TBS) in milk. Samples were extracted with ethyl acetate and...

Immunological detection of chemotherapeutic success in bovine fasciolosis using the specific antigen f2.

Vet. Parasitol. 45(1-2) , 81-8, (1992)

An improved hemagglutination (HA) test using the purified specific f2 antigen of Fasciola hepatica has been evaluated with regard to its potential use for the prediction of chemotherapeutic success in...

2,3,5-Trichlor-N-(3,5-dichlor-2-hydroxyphenyl)-6-hydroxybenzolcarboxamid

MFCD00864507

Zanilox

Oxyclozanide

diplin

3,3',5,5',6-Pentachloro-2'-hydroxysalicylanilid

EINECS 218-904-0

OXYCLOZAMIDE

Oxycloxanide

zanil

Saucylanilide

Benzamide, 2,3,5-trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxy-

3,3',5,5',6-pentachloro-2'-hydroxysalicylanilide

2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide

oxyclozanid

DC Chemicals Limited
China
Product Name: Oxyclozanide
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Oxyclozanide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Oxyclozanide
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Oxyclozanide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Price: $79/10mM*1mLinDMSO

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Oxyclozanide

Use of Oxyclozanide

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Oxyclozanide Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

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