Vamidothion

Modify Date: 2025-08-21 10:18:53

Vamidothion Structure
Vamidothion structure
 Common Name Vamidothion
CAS Number 2275-23-2 Molecular Weight 287.337
Density 1.2±0.1 g/cm3 Boiling Point N/A
Molecular Formula C8H18NO4PS2 Melting Point 43ºC
MSDS Chinese Flash Point 2 °C
Symbol GHS02 GHS07
GHS02, GHS07		 Signal Word Danger

 Names

Name vamidothion
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Melting Point 43ºC
Molecular Formula C8H18NO4PS2
Molecular Weight 287.337
Flash Point 2 °C
Exact Mass 287.041473
PSA 125.04000
LogP 0.15
Index of Refraction 1.508

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TF7900000
CHEMICAL NAME :
Phosphorothioic acid, O,O-dimethyl ester, S-ester with 2-((2-mercaptoethyl)thio)-N- methylpropionamide
CAS REGISTRY NUMBER :
2275-23-2
LAST UPDATED :
199801
DATA ITEMS CITED :
25
MOLECULAR FORMULA :
C8-H18-N-O4-P-S2
MOLECULAR WEIGHT :
287.36
WISWESSER LINE NOTATION :
1OPO&O1&S2SY1&VM1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1730 mg/m3/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
64 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
40 mg/kg
TOXIC EFFECTS :
Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1460 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
43 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
117 mg/kg
TOXIC EFFECTS :
Behavioral - ataxia Behavioral - coma Kidney, Ureter, Bladder - urine volume increased
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1160 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
85 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
85 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Bird - wild bird species
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
678 mg/kg/17W-I
TOXIC EFFECTS :
Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
375 mg/kg/1Y-I
TOXIC EFFECTS :
Endocrine - changes in adrenal weight Blood - normocytic anemia Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1020 ug/m3/24/22W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
420 mg/kg/15W-I
TOXIC EFFECTS :
Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.) Liver - hepatitis (hepatocellular necrosis), diffuse Nutritional and Gross Metabolic - weight loss or decreased weight gain

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
1 mmol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 78,177,1980 *** REVIEWS *** TOXICOLOGY REVIEW RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 63,1,1976

 Safety Information

Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger
Hazard Statements H225-H302 + H312 + H332-H319
Precautionary Statements P210-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T: Toxic;N: Dangerous for the environment;
Risk Phrases R21;R25;R50
Safety Phrases S36/37-S45-S61-S16
RIDADR UN 2811
RTECS TF7900000
Packaging Group III
Hazard Class 6.1(b)

 Articles2

More Articles
Determination of polar organophosphorus pesticides in water samples by hydrophilic interaction liquid chromatography with tandem mass spectrometry.

Rapid Commun. Mass Spectrom. 22(14) , 2203-10, (2008)

A method combining hydrophilic interaction liquid chromatography (HILIC) with tandem mass spectrometry (MS/MS) was developed for the determination of polar organophosphorus pesticides (OPPs; acephate,...

Evaluation of residual levels of benomyl, methyl parathion, diuron, and vamidothion in pineapple pulp and bagasse (Smooth cayenne).

J. Agric. Food Chem. 48(11) , 5750-3, (2000)

The objective of this research was to study the residual levels of benomyl, methyl parathion, diuron, and vamidothion in pineapple bagasse and pulp. Benomyl (benlate), methyl parathion (Folidol 600), ...

 Synonyms

O,O-dimethyl S-[2-[[1-methyl-2-(methylamino)-2-oxoethyl]thio]ethyl] phosphorothioate
O,O-Dimethyl S-(2-{[1-(methylamino)-1-oxo-2-propanyl]sulfanyl}ethyl) phosphorothioate
Kilval
(RS)-2-(2-dimethoxyphosphinoylthioethylthio)-N-methylpropionamide
2-(2-dimethoxyphosphorylsulfanylethylsulfanyl)-N-methylpropanamide
O,O-Dimethyl S-[2-(1-methyl-2-methylamino-2-oxoethylthio)ethyl] phosphorothioate
O,O-Dimethyl S-(2-((1-methyl-2-(methylamino)-2-oxoethyl)thio)ethyl) phosphorothioate (9CI)
O,O-Dimethyl S-(2-{[1-(methylamino)-1-oxopropan-2-yl]sulfanyl}ethyl) phosphorothioate
rac-O,O-dimethyl S-(2-{[(2R)-1-(methylamino)-1-oxopropan-2-yl]sulfanyl}ethyl) phosphorothioate
O,O-Dimethyl-S-(2-{[1-(methylamino)-1-oxopropan-2-yl]sulfanyl}ethyl)thiophosphat
Vamidothion
MFCD00055442
Phosphorothioic acid, O,O-dimethyl S-[2-[[1-methyl-2-(methylamino)-2-oxoethyl]thio]ethyl] ester
EINECS 218-894-8
NPH 83
O,O-dimethyl S-(RS)-2-(1-methylcarbamoylethylthio)ethyl phosphorothioate
Thiophosphate de S-(2-{[1-(méthylamino)-1-oxo-2-propanyl]sulfanyl}éthyle) et de O,O-diméthyle
Vamidoate
O,O-Dimethyl-S-(2-{[1-(methylamino)-1-oxo-2-propanyl]sulfanyl}ethyl)thiophosphat
Trucidor
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