Aminocandin
Modify Date: 2024-01-10 16:40:37
Aminocandin structure
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Common Name | Aminocandin | ||
|---|---|---|---|---|
| CAS Number | 227472-48-2 | Molecular Weight | 1102.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C56H79N9O14 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AminocandinAminocandin (HMR 3270) is water-soluble antifungal drug of the echinocandin class with excellent activity against Aspergillus and Candida spp.[1]. |
| Name | Aminocandin |
|---|
| Description | Aminocandin (HMR 3270) is water-soluble antifungal drug of the echinocandin class with excellent activity against Aspergillus and Candida spp.[1]. |
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| Related Catalog | |
| Target |
Fungal[1] |
| In Vitro | Aminocandin (HMR 3270) inhibits Fluconazole (HY-B0101)-resistant C. albicans strain MRL 648 with an MIC of 0.25 mg/L[2]. Aminocandin shows half-life of 48-58 h[2]. |
| In Vivo | Aminocandin (1-10 mg/kg; i.v. or i.p.; once daily for 11 days) is highly effective in reducing mortality and organ burden in disseminated infection caused by ITC-susceptible and -resistant A. fumigatus in mice[1]. Aminocandin (5 and 10 mg/kg; i.v.; once or twice a week for 4 weeks) is an effective addition to the arsenal of antifungal compounds for the treatment of candidiasis caused by Fluconazole (HY-B0101)-resistant C. albicans in immunocompetent mice[2]. Animal Model: Immunosuppressed male CD1 mice, Aspergillus fumigatus infection model[1] Dosage: 10, 5, 1 and 0.25 mg/kg (IV) or 1 mg/kg (IP) Administration: IV or IP, once daily for 11 days Result: Increased the survival rate, 5 mg/kg i.v. yielded 100% survival following infection with AF91. |
| Molecular Formula | C56H79N9O14 |
|---|---|
| Molecular Weight | 1102.28 |