Aminocandin

Aminocandin (HMR 3270) is water-soluble antifungal drug of the echinocandin class with excellent activity against Aspergillus and Candida spp.[1].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

Fungal[1]

Aminocandin (HMR 3270) inhibits Fluconazole (HY-B0101)-resistant C. albicans strain MRL 648 with an MIC of 0.25 mg/L[2]. Aminocandin shows half-life of 48-58 h[2].

Aminocandin (1-10 mg/kg; i.v. or i.p.; once daily for 11 days) is highly effective in reducing mortality and organ burden in disseminated infection caused by ITC-susceptible and -resistant A. fumigatus in mice[1]. Aminocandin (5 and 10 mg/kg; i.v.; once or twice a week for 4 weeks) is an effective addition to the arsenal of antifungal compounds for the treatment of candidiasis caused by Fluconazole (HY-B0101)-resistant C. albicans in immunocompetent mice[2]. Animal Model: Immunosuppressed male CD1 mice, Aspergillus fumigatus infection model[1] Dosage: 10, 5, 1 and 0.25 mg/kg (IV) or 1 mg/kg (IP) Administration: IV or IP, once daily for 11 days Result: Increased the survival rate, 5 mg/kg i.v. yielded 100% survival following infection with AF91.