6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol

Modify Date: 2024-01-22 10:52:36

6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol structure	Common Name	6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
	CAS Number	226907-52-4	Molecular Weight	315.327
	Density	1.4±0.1 g/cm3	Boiling Point	626.4±65.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₇N₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	332.6±34.3 °C

Use of 6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol

SM-360320 (CL-087) is a potent, oral actively TLR7 agonist. SM-360320 is a mmuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].

Name	6-amino-9-benzyl-2-(2-methoxyethoxy)-7H-purin-8-one
Synonym	More Synonyms

Description	SM-360320 (CL-087) is a potent, oral actively TLR7 agonist. SM-360320 is a mmuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR) Research Areas >> Inflammation/Immunology
References	[1]. Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472. [2]. Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833.

Description

Related Catalog

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Research Areas >> Inflammation/Immunology

References

[1]. Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472.

[2]. Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833.

Density	1.4±0.1 g/cm3
Boiling Point	626.4±65.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₇N₅O₃
Molecular Weight	315.327
Flash Point	332.6±34.3 °C
Exact Mass	315.133148
PSA	108.31000
LogP	0.21
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.675

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

9-Benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine

Toll-Like Receptor 7 Ligand II

TLR7 Ligand II

6-Amino-9-benzyl-2-(2-methoxyethoxy)-7,9-dihydro-8H-purin-8-one

6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol

8H-Purin-8-one, 6-amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-

DC Chemicals Limited
China
Product Name: SM360320
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6-AMINO-9-BENZYL-2-(2-METHOXYETHOXY)-9H-PURIN-8-OL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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