6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol

Names

[ Name ]:
6-amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol

[Synonym ]:
9-Benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine
Toll-Like Receptor 7 Ligand II
TLR7 Ligand II
6-Amino-9-benzyl-2-(2-methoxyethoxy)-7,9-dihydro-8H-purin-8-one
6-Amino-9-benzyl-2-(2-methoxyethoxy)-9H-purin-8-ol
8H-Purin-8-one, 6-amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-

Biological Activity

[Description]:

SM-360320 (CL-087) is a potent, oral actively TLR7 agonist. SM-360320 is a mmuno-modulator and exerts an antitumor effect. SM-360320 can act in synergy with DNA vaccines leading to an enhanced Th1 antibody response[1]. SM-360320 can inhibit HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity[2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Toll-like Receptor (TLR)

Research Areas >> Inflammation/Immunology

[References]

[1]. Dharmapuri S, et al. An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models. Cancer Gene Ther. 2009;16(5):462-472.

[2]. Lee J, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103(6):1828-1833.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
626.4±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₅H₁₇N₅O₃

[ Molecular Weight ]:
315.327

[ Flash Point ]:
332.6±34.3 °C

[ Exact Mass ]:
315.133148

[ PSA ]:
108.31000

[ LogP ]:
0.21

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.675

Safety Information

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%