SJFα

Modify Date: 2025-10-01 18:00:33

SJFα Structure
SJFα structure
 Common Name SJFα
CAS Number 2254609-27-1 Molecular Weight 1120.27
Density N/A Boiling Point N/A
Molecular Formula C59H67F2N7O11S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SJFα


SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16  nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].

 Names

Name SJFα

 SJFα Biological Activity

Description SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16  nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].
Related Catalog
Target

p38α:7.16 nM (DC50)

p38δ:299 nM (DC50)

PROTAC

References

[1]. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131.

 Chemical & Physical Properties

Molecular Formula C59H67F2N7O11S
Molecular Weight 1120.27

 Safety Information

Hazard Codes Xi
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Chemsrc provides SJFα(CAS#:2254609-27-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of SJFα are included as well.>> amp version: SJFα

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