AUTAC2

Modify Date: 2025-08-24 21:03:47

AUTAC2 structure	Common Name	AUTAC2
	CAS Number	2241669-08-7	Molecular Weight	1229.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₁H₈₁FN₁₀O₁₄S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AUTAC2

AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12[1].

Name	AUTAC2

Description	AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Inflammation/Immunology
In Vitro	AUTAC1 (1-100 μM, 24 h) silences endogenous FKBP12 in hela cells[1]. Western Blot Analysis[1] Cell Line: HeLa cells. Concentration: 0-100 μM. Incubation Time: 24 h. Result: Silenced endogenous FKBP12.
References	[1]. Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.

Molecular Formula	C₆₁H₈₁FN₁₀O₁₄S
Molecular Weight	1229.42

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