AUTAC2

Names

[ CAS No. ]:
2241669-08-7

[ Name ]:
AUTAC2

Biological Activity

[Description]:

AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Autophagy >> Autophagy
Research Areas >> Inflammation/Immunology

[In Vitro]

AUTAC1 (1-100 μM, 24 h) silences endogenous FKBP12 in hela cells[1]. Western Blot Analysis[1] Cell Line: HeLa cells. Concentration: 0-100 μM. Incubation Time: 24 h. Result: Silenced endogenous FKBP12.

[References]

[1]. Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.

Chemical & Physical Properties

[ Molecular Formula ]:
C61H81FN10O14S

[ Molecular Weight ]:
1229.42


Related Compounds

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