KRAS inhibitor-12
Modify Date: 2025-08-25 10:27:42
KRAS inhibitor-12 structure
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Common Name | KRAS inhibitor-12 | ||
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| CAS Number | 2230874-00-5 | Molecular Weight | 452.33 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H16Cl2FN5OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KRAS inhibitor-12KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
| Name | KRAS inhibitor-12 |
|---|
| Description | KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1]. |
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| Related Catalog | |
| Target |
KRas G12C:0.537 μM (IC50) |
| References |
[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2 |
| Molecular Formula | C19H16Cl2FN5OS |
|---|---|
| Molecular Weight | 452.33 |