TL 13-22
Modify Date: 2025-08-26 05:50:47
TL 13-22 structure
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Common Name | TL 13-22 | ||
|---|---|---|---|---|
| CAS Number | 2229036-65-9 | Molecular Weight | 947.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C45H55ClN10O9S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TL 13-22TL13-22 is a negative control for TL13-12 (HY-122582) and a potent ALK inhibitor with an IC50 of 0.54 nM. TL13-22 does not degrade ALK in cells[1]. |
| Name | TL13-22 |
|---|
| Description | TL13-22 is a negative control for TL13-12 (HY-122582) and a potent ALK inhibitor with an IC50 of 0.54 nM. TL13-22 does not degrade ALK in cells[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.54 nM (ALK)[1] |
| In Vitro | TL13-22 prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 11.3 nM, 5.74 nM, 18.4 nM, and 65.9 nM, respectively[1]. |
| References |
| Molecular Formula | C45H55ClN10O9S |
|---|---|
| Molecular Weight | 947.50 |
| InChIKey | JVBGYTWMZKXATO-UHFFFAOYSA-N |
| SMILES | COc1cc(N2CCN(CCOCCOCCNC(=O)CNc3cccc4c3C(=O)N(C3CCCNC3=O)C4=O)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1 |