FM-479

Modify Date: 2025-08-26 23:19:41

FM-479 structure	Common Name	FM-479
	CAS Number	2226521-64-6	Molecular Weight	442.51
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₆N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of FM-479

FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.

Name	FM-479

Description	FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases[1]. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
Related Catalog	Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Research Areas >> Inflammation/Immunology
Target	JAK3
In Vitro	FM-479 is the inactive control of FM-381, the concentration used in assays is similar[1].
References	[1]. https://www.thesgc.org/chemical-probes/FM-381

Molecular Formula	C₂₅H₂₆N₆O₂
Molecular Weight	442.51

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China
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China
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China
Product Name: FM-479
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FM-479

Use of FM-479

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FM-479 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.