N-Isopropylacrylamide

Modify Date: 2025-08-21 20:26:26

N-Isopropylacrylamide structure	Common Name	N-Isopropylacrylamide
	CAS Number	2210-25-5	Molecular Weight	113.158
	Density	0.9±0.1 g/cm3	Boiling Point	225.1±13.0 °C at 760 mmHg
	Molecular Formula	C₆H₁₁NO	Melting Point	60-63 °C(lit.)
	MSDS	Chinese USA	Flash Point	119.7±4.8 °C
	Symbol	GHS07	Signal Word	Warning

Name	N-propan-2-ylprop-2-enamide
Synonym	More Synonyms

Density	0.9±0.1 g/cm3
Boiling Point	225.1±13.0 °C at 760 mmHg
Melting Point	60-63 °C(lit.)
Molecular Formula	C₆H₁₁NO
Molecular Weight	113.158
Flash Point	119.7±4.8 °C
Exact Mass	113.084061
PSA	29.10000
LogP	0.19
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.428
Storage condition	0-6°C

N-Isopropylacrylamide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AS3675000

CHEMICAL NAME :: Acrylamide, N-isopropyl-

CAS REGISTRY NUMBER :: 2210-25-5

BEILSTEIN REFERENCE NO. :: 1744926

LAST UPDATED :: 199710

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C6-H11-N-O

MOLECULAR WEIGHT :: 113.18

WISWESSER LINE NOTATION :: 1Y1&MV1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 375 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Lungs, Thorax, or Respiration - other changes Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 419 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1580 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Lungs, Thorax, or Respiration - other changes Blood - hemorrhage

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2173 mg/kg/8W-I

TOXIC EFFECTS :: Related to Chronic Data - changes in testicular weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2235 mg/kg

SEX/DURATION :: male 16 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 238 gm/kg

SEX/DURATION :: male 5 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 158 gm/kg

SEX/DURATION :: male 5 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 238 mg/kg/5W (Continuous)

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 59,201,1986

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36/37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	AS3675000
HS Code	2924199090

isopropylamine

CAS#:75-31-0

Acrylic acid

CAS#:79-10-7

~57%

N-Isopropylacry...

CAS#:2210-25-5

Literature: Nomura, Ryoki; Nakano, Takahiro; Yamada, Yasuhiro; Matsuda, Haruo Journal of Organic Chemistry, 1991 , vol. 56, # 12 p. 4076 - 4078

isopropylamine

CAS#:75-31-0

Hydroxypropioni...

CAS#:503-66-2

~24%

N-Isopropylacry...

CAS#:2210-25-5

Acrylic acid

CAS#:79-10-7

Literature: US2005/222458 A1, ; Page/Page column 10 ;

Acrylonitrile

CAS#:107-13-1

Isopropanol

CAS#:67-63-0

~93%

N-Isopropylacry...

CAS#:2210-25-5

Literature: Chen, Xin; Matsuda, Hideho; Okuhara, Toshio Chemistry Letters, 1999 , # 8 p. 799 - 800

Acrylic acid

CAS#:79-10-7

N-Isopropylacry...

CAS#:2210-25-5

Literature: US5226902 A1, ;

isopropylamine

CAS#:75-31-0

acrylic acid me...

CAS#:292638-85-8

N-Isopropylacry...

CAS#:2210-25-5

Literature: US2719175 , ;

3-CHLORO-N-ISOP...

CAS#:22813-48-5

Triethylamine

CAS#:121-44-8

N-Isopropylacry...

CAS#:2210-25-5

Literature: DE932964 , ;

isopropylamine

CAS#:75-31-0

Acrylyl chloride

CAS#:814-68-6

N-Isopropylacry...

CAS#:2210-25-5

Literature: Journal of Organic Chemistry, , vol. 70, # 20 p. 7810 - 7815

N-allyl-N-isopr...

CAS#:57934-24-4

N-Isopropylacry...

CAS#:2210-25-5

Literature: Journal fuer Praktische Chemie (Leipzig), , vol. 318, p. 471 - 478

propene

CAS#:187737-37-7

Acrylonitrile

CAS#:107-13-1

N-Isopropylacry...

CAS#:2210-25-5

Literature: US2719176 , ;

Precursor 10
CAS#:75-31-0 isopropylamine CAS#:79-10-7 Acrylic acid CAS#:503-66-2 Hydroxypropioni... CAS#:107-13-1 Acrylonitrile
CAS#:67-63-0 Isopropanol CAS#:292638-85-8 acrylic acid me... CAS#:22813-48-5 3-CHLORO-N-ISOP... CAS#:121-44-8 Triethylamine
CAS#:814-68-6 Acrylyl chloride CAS#:57934-24-4 N-allyl-N-isopr...
DownStream 4
CAS#:10601-63-5 Propanamide,N-(... CAS#:75-31-0 isopropylamine CAS#:79-10-7 Acrylic acid CAS#:56146-87-3 N-Isopropyl-3-p...

HS Code	2924199090
Summary	2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Abatement of aqueous anionic contaminants by thermo-responsive nanocomposites: (poly(N-isopropylacrylamide))-co-silylanized magnesium/aluminun layered double hydroxides.

J. Colloid. Interface Sci. 448 , 65-72, (2015)

A series of novel thermo-responsive composite sorbents, were prepared by free-radical co-polymerization of N-isopropylacrylamide (NIPAm) and the silylanized Mg/Al layered double hydroxides (SiLDHs), n...

Bioactive thermoresponsive polyblend nanofiber formulations for wound healing.

Mater. Sci. Eng. C. Mater. Biol. Appl. 48 , 126-37, (2015)

The rationale of this work is to develop new bioactive thermoresponsive polyblend nanofiber formulations for wound healing (topical). Various polymer compositions of thermoresponsive, poly(N-isopropyl...

Controlling osteogenic stem cell differentiation via soft bioinspired hydrogels.

PLoS ONE 9(6) , e98640, (2014)

Osteogenic differentiation of human mesenchymal stem cells (hMSCs) is guided by various physical and biochemical factors. Among these factors, modulus (i.e., rigidiy) of the ECM has gained significant...

2-Propenamide, N-(1-methylethyl)-

N-(isopropyl)acrylamide

2-Propenamide,N-(1-methylethyl)

N-(1-Methylethyl)-2-propenamide

N-Isopropylacrylamide,stabilized

Isopropyl acrylamide

N-(1-methylethyl)prop-2-enamide

N-isopropyl acrylamide

MFCD00041913

N-Isopropylacrylamide

Acrylamide,N-isopropyl

Nipam

EINECS 218-638-5

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: N-Isopropylacrylamide
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: N-Isopropylacrylamide
Price: ￥588.0/100g ￥188.0/25g
Purity: 98.0%
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-Isopropylacrylamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: N-Isopropylacrylamide
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

Zhongshan Xingrui Chemical Co. , Ltd.
China
Product Name: N-Isopropylacrylamide
Price: ￥Inquiry/25kg
Purity: 99.0%
Delivery: Inquiry
Contact: Wang Jie
Email: 3096638339@qq.com

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N-Isopropylacrylamide

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Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

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