M-525
Modify Date: 2025-08-21 18:35:43
M-525 structure
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Common Name | M-525 | ||
|---|---|---|---|---|
| CAS Number | 2173582-08-4 | Molecular Weight | 734.932 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H51FN6O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of M-525M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays; inhibits MV4;11 (MLL fusion) and HL60 (No MLL fusion) cell growth with IC50 of 2.7 and 2,000 nM, respectively; significantly down-regulates the expression of MEIS1, HOXA9 and HOXA11 genes in a dosedependent anner at ow nanomolar concentrations, also effectively suppresses the expression of MEIS1 and HOX genes in the MOLM-13 cell line at 3 nM. |
| Name | M-525 |
|---|
| Description | M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction with binding IC50 of 3.3 nM in FP assays; inhibits MV4;11 (MLL fusion) and HL60 (No MLL fusion) cell growth with IC50 of 2.7 and 2,000 nM, respectively; significantly down-regulates the expression of MEIS1, HOXA9 and HOXA11 genes in a dosedependent anner at ow nanomolar concentrations, also effectively suppresses the expression of MEIS1 and HOX genes in the MOLM-13 cell line at 3 nM. |
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| References | References 1. Xu S, et al. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605. View Related Products by Target Histone Methyltransferase (HMTase) |
| Molecular Formula | C39H51FN6O5S |
|---|---|
| Molecular Weight | 734.932 |
| InChIKey | PJMFCNODKBGQNV-HDDNKGPMSA-N |
| SMILES | COC(=O)NC1CCCC1C(C#N)(c1cccc(F)c1)C1CCN(CC2CN(c3ccc(S(=O)(=O)C4CN(C(=O)C=CCN(C)C)C4)cc3)C2)CC1 |