Metapramine

Modify Date: 2024-01-11 06:15:27

Metapramine structure	Common Name	Metapramine
	CAS Number	21730-16-5	Molecular Weight	238.32800
	Density	1.12g/cm3	Boiling Point	350.8ºC at 760mmHg
	Molecular Formula	C₁₆H₁₈N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	140.7ºC

Use of Metapramine

Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds[1]. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine[1] [2] [3]. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel[4].

Name	N,11-dimethyl-5,6-dihydrobenzo[b][1]benzazepin-5-amine
Synonym	More Synonyms

Description	Metapramine (19560 RP) is an antidepressant agent, belonging to the class of tricyclic compounds[1]. Metapramine inhibits norepinephrine reuptake, without affecting the reuptake of serotonin or dopamine[1] [2] [3]. Metapramine is a low-affinity antagonist of the N-methyl-D-aspartic acid (NMDA) receptor complex channel[4].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	NMDA receptor complex channel[4]
In Vivo	Metapramine (19560 RP) (0-20 mg/kg; i.p.) shows analgesic effects in mice[5]. Animal Model: Male Swiss albino mice[5] Dosage: 0-20 mg/kg Administration: Intraperitoneal injection Result: Increased jump latency, threshold voltage, reduction in writhes, and tail flick latency in a dose-dependent manner.
References	[1]. M Bonierbale, et al. [Metapramine: antidepressant and psycho-stimulant]. Encephale. 1976;2(3):219-23. [2]. H Dagonneau, et al. [Effects, in rats, of metapramine and carpipramine on the uptake of catecholamines and serotonin; relationship with 3H-imipramine binding]. C R Seances Soc Biol Fil. 1986;180(1):43-8. [3]. J M Warter, et al. Immediate effects of 14 non MAOI antidepressants in rats with spontaneous petit mal-like seizures. Prog Neuropsychopharmacol Biol Psychiatry. 1990;14(2):261-70. [4]. A Boireau, et al. The antidepressant metapramine is a low-affinity antagonist at N-methyl-D-aspartic acid receptors. Neuropharmacology. 1996;35(12):1703-7. [5]. Adina Michael-Titus, et al. Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Pain. 1987 Dec;31(3):391-400. doi: 10.1016/0304-3959(87)90167-9.

Density	1.12g/cm3
Boiling Point	350.8ºC at 760mmHg
Molecular Formula	C₁₆H₁₈N₂
Molecular Weight	238.32800
Flash Point	140.7ºC
Exact Mass	238.14700
PSA	15.27000
LogP	3.72700
Vapour Pressure	4.27E-05mmHg at 25°C
Index of Refraction	1.633

HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Metapramine

Metapramina

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Metapramine
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China
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Metapramine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Metapramine

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