RMC-4550
Modify Date: 2024-01-13 11:29:21
RMC-4550 structure
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Common Name | RMC-4550 | ||
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| CAS Number | 2172651-73-7 | Molecular Weight | 437.36 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H26Cl2N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RMC-4550RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM. |
| Name | RMC-4550 |
|---|
| Description | RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM. |
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| Related Catalog | |
| Target |
IC50:0.583 nM (SHP2)[1]. |
| In Vitro | RMC-4550 is an allosteric inhibitor of SHP2 and stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. Consistent with an allosteric mode of inhibition, RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2[1]. |
| References |
| Molecular Formula | C21H26Cl2N4O2 |
|---|---|
| Molecular Weight | 437.36 |
| Storage condition | 2-8℃ |