PZ-2891

Modify Date: 2025-08-25 18:06:33

PZ-2891 Structure
PZ-2891 structure
Common Name PZ-2891
CAS Number 2170608-82-7 Molecular Weight 349.43
Density N/A Boiling Point N/A
Molecular Formula C20H23N5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PZ-2891


PZ-2891 is an oral, allosteric, and brain penetrant pantothenate kinase (PANK) modulator, acting as both an orthosteric inhibitor (IC50=1.3 nM) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA.

 Names

Name PZ-2891

 PZ-2891 Biological Activity

Description PZ-2891 is an oral, allosteric, and brain penetrant pantothenate kinase (PANK) modulator, acting as both an orthosteric inhibitor (IC50=1.3 nM) and an allosteric activator of PANK3 activity in the presence of acetyl-CoA.
Related Catalog
Target

IC50: 1.3 nM (PANK)[1]

References

[1]. Sharma LK, et al. A therapeutic approach to pantothenate kinase associated neurodegeneration. Nat Commun. 2018 Oct 23;9(1):4399.

 Chemical & Physical Properties

Molecular Formula C20H23N5O
Molecular Weight 349.43
Storage condition 2-8℃
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