ε-Amanitin
Modify Date: 2024-01-05 13:30:49
ε-Amanitin structure
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Common Name | ε-Amanitin | ||
|---|---|---|---|---|
| CAS Number | 21705-02-2 | Molecular Weight | 903.95500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H53N9O14S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ε-Amanitinε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II[1][2]. |
| Name | ε-Amanitin |
|---|---|
| Synonym | More Synonyms |
| Description | ε-Amanitin, a cyclic peptide isolated from a variety of mushroom species, potently binds to and inhibits the activity of RNA polymerase II[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Traditional Cytotoxic Agents |
| In Vitro | Amatoxin Family includes alpha-Amanitin, beta-Amanitin, gamma-Amanitin, epsilon-Amanitin (ε-Amanitin), Amanullin, Amanullinic acid, Amaninamide, Amanin and Proamanullin. Amatoxins are potent and selective inhibitors of RNA polymerase II, a vital enzyme in the synthesis of messenger RNA (mRNA), microRNA, and small nuclear RNA (snRNA). By inhibiting the synthesis of mRNA, Amatoxins thereby stop cell metabolism by inhibiting transcription and protein biosynthesis, which results in cellular apoptosis. Consequently Amatoxins stop cell growth and proliferation[1]. |
| References |
| Molecular Formula | C39H53N9O14S |
|---|---|
| Molecular Weight | 903.95500 |
| Exact Mass | 903.34300 |
| PSA | 374.07000 |
| epsilon-Amanitin |
| Amanine |