Tetrahydropyranyldiethyleneglycol

Modify Date: 2024-01-11 18:45:50

Tetrahydropyranyldiethyleneglycol Structure
Tetrahydropyranyldiethyleneglycol structure
Common Name Tetrahydropyranyldiethyleneglycol
CAS Number 2163-11-3 Molecular Weight 190.23700
Density N/A Boiling Point N/A
Molecular Formula C9H18O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tetrahydropyranyldiethyleneglycol


Tetrahydropyranyldiethyleneglycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Tetrahydropyranyldiethyleneglycol
Synonym More Synonyms

 Tetrahydropyranyldiethyleneglycol Biological Activity

Description Tetrahydropyranyldiethyleneglycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C9H18O4
Molecular Weight 190.23700
Exact Mass 190.12100
PSA 47.92000
LogP 0.53850

 Safety Information

HS Code 2932999099

 Synthetic Route

~56%

Tetrahydropyranyldiethyleneglycol Structure

Tetrahydropyran...

CAS#:2163-11-3

Literature: UNIVERSITY OF MARYLAND, COLLEGE PARK; UNIVERSITY OF MARYLAND, BALTIMORE; YU, YIHUA (BRUCE); YUE, XUYI Patent: US2013/197271 A1, 2013 ; Location in patent: Paragraph 0105 ;

~69%

Tetrahydropyranyldiethyleneglycol Structure

Tetrahydropyran...

CAS#:2163-11-3

Literature: Liu, Xiao; Tian, Zhicheng; Chen, Chen; Allcock, Harry R. Macromolecules, 2012 , vol. 45, # 3 p. 1417 - 1426

 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-[2-(oxan-2-yloxy)ethoxy]ethanol
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