2163-11-3
2163-11-3 structure
- Name: Tetrahydropyranyldiethyleneglycol
- Chemical Name: Tetrahydropyranyldiethyleneglycol
- CAS Number: 2163-11-3
- Molecular Formula: C9H18O4
- Molecular Weight: 190.23700
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-08-23 20:17:14
- Modify Date: 2024-01-11 18:45:50
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Tetrahydropyranyldiethyleneglycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | Tetrahydropyranyldiethyleneglycol |
|---|---|
| Synonyms | 2-[2-(oxan-2-yloxy)ethoxy]ethanol |
| Description | Tetrahydropyranyldiethyleneglycol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C9H18O4 |
|---|---|
| Molecular Weight | 190.23700 |
| Exact Mass | 190.12100 |
| PSA | 47.92000 |
| LogP | 0.53850 |
| HS Code | 2932999099 |
|---|
|
~56%
2163-11-3 |
| Literature: UNIVERSITY OF MARYLAND, COLLEGE PARK; UNIVERSITY OF MARYLAND, BALTIMORE; YU, YIHUA (BRUCE); YUE, XUYI Patent: US2013/197271 A1, 2013 ; Location in patent: Paragraph 0105 ; |
|
~69%
2163-11-3 |
| Literature: Liu, Xiao; Tian, Zhicheng; Chen, Chen; Allcock, Harry R. Macromolecules, 2012 , vol. 45, # 3 p. 1417 - 1426 |
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |