KRAS-G12C inhibitor 13
Modify Date: 2024-01-09 12:13:05
KRAS-G12C inhibitor 13 structure
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Common Name | KRAS-G12C inhibitor 13 | ||
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| CAS Number | 2158296-45-6 | Molecular Weight | 528.657 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H36N6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of KRAS-G12C inhibitor 13KRAS-G12C inhibitor 13 is a potnt, irreversible, covalent and in vivo-active inhibitor of KRAS-G12C, suppresses ERK phosphorylation with IC50 of 70 nM in H358 cell assays; displays no significant activity against non-G12C cell lines with IC50 of >16 uM; demonstrates KRAS-G12C target engagement in vivo and antitumor efficacy in the MIA PaCa-2 tumor xenograft models. |
| Name | KRAS-G12C inhibitor 13 |
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| Description | KRAS-G12C inhibitor 13 is a potnt, irreversible, covalent and in vivo-active inhibitor of KRAS-G12C, suppresses ERK phosphorylation with IC50 of 70 nM in H358 cell assays; displays no significant activity against non-G12C cell lines with IC50 of >16 uM; demonstrates KRAS-G12C target engagement in vivo and antitumor efficacy in the MIA PaCa-2 tumor xenograft models. |
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| References | References 1. Jay B. Fell, et al. Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.8b00382. View Related Products by Target Ras |
| Molecular Formula | C30H36N6O3 |
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| Molecular Weight | 528.657 |