Selpercatinib (LOXO-292)
Modify Date: 2025-08-25 17:01:45
Selpercatinib (LOXO-292) structure
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Common Name | Selpercatinib (LOXO-292) | ||
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| CAS Number | 2152628-33-4 | Molecular Weight | 525.60 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H31N7O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Selpercatinib (LOXO-292)Selpercatinib is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 163, has an IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively[1]. Antineoplastic activity[2]. |
| Name | Selpercatinib |
|---|
| Description | Selpercatinib is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 163, has an IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M) , and RET (G810R), respectively[1]. Antineoplastic activity[2]. |
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| Related Catalog | |
| Target |
IC50: 14.0 nM (RETWT), 24.1 nM (RETV804M), 530.7 nM (RETG810R)[1] |
| References |
| Molecular Formula | C29H31N7O3 |
|---|---|
| Molecular Weight | 525.60 |
| InChIKey | XIIOFHFUYBLOLW-UHFFFAOYSA-N |
| SMILES | COc1ccc(CN2C3CC2CN(c2ccc(-c4cc(OCC(C)(C)O)cn5ncc(C#N)c45)cn2)C3)cn1 |