AZD-5991 S-enantiomer

Modify Date: 2025-08-26 19:00:33

AZD-5991 S-enantiomer Structure
AZD-5991 S-enantiomer structure
 Common Name AZD-5991 S-enantiomer
CAS Number 2143061-82-7 Molecular Weight 672.26
Density N/A Boiling Point N/A
Molecular Formula C35H34ClN5O3S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AZD-5991 S-enantiomer


AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.

 Names

Name AZD-5991 S-enantiomer

 AZD-5991 S-enantiomer Biological Activity

Description AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.
Related Catalog
Target

Mcl-1:6.3 μM (IC50)

Mcl-1:0.98 μM (Kd)

References

[1]. Tron AE, et al. Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia. Nat Commun. 2018 Dec 17;9(1):5341.

 Chemical & Physical Properties

Molecular Formula C35H34ClN5O3S2
Molecular Weight 672.26
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Chemsrc provides AZD-5991 S-enantiomer(CAS#:2143061-82-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of AZD-5991 S-enantiomer are included as well.>> amp version: AZD-5991 S-enantiomer

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