6H-Purine-6-thione,2-amino-9-(2-deoxy-a-D-erythro-pentofuranosyl)-1,9-dihydro-

MOLECULAR FORMULA :

C10-H13-N5-O3-S

MOLECULAR WEIGHT :

283.34

WISWESSER LINE NOTATION :

T56 BN DN FYM INJ FUS HZ B- ET5OTJ B1Q CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

1 gm/kg/5D-I

TOXIC EFFECTS :

Gastrointestinal - nausea or vomiting Related to Chronic Data - death

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

1500 mg/kg/33D-I

TOXIC EFFECTS :

Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Primate - monkey

DOSE/DURATION :

3 gm/kg/5D-I

TOXIC EFFECTS :

Gastrointestinal - nausea or vomiting Blood - agranulocytosis Skin and Appendages - dermatitis, other (after systemic exposure)

MUTATION DATA

TYPE OF TEST :

Host-mediated assay

TEST SYSTEM :

Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :

100 umol/kg

REFERENCE :

CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,1103,1975