GNE-2256
Modify Date: 2024-01-19 18:17:59
GNE-2256 structure
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Common Name | GNE-2256 | ||
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| CAS Number | 2102170-43-2 | Molecular Weight | 482.516 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H27FN6O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GNE-2256GNE-2256 (GNE2256) is a potent, selective inhibitor of IRAK4 with biochemical Ki of 1.4 nM.GNE-2256 displays high selectivity in the CEREP panel with off-targets with >50% inhibition are TACR1, HTR2B and ACHE.GNE-2256 is potent in the NanoBRET assay (IC50 = 3.3 nM), the IL-6 human whole blood assay (IC50=190 nM) and the IFNα human whole blood assay (IC50=290 nM). |
| Name | GNE-2256 |
|---|
| Description | GNE-2256 (GNE2256) is a potent, selective inhibitor of IRAK4 with biochemical Ki of 1.4 nM.GNE-2256 displays high selectivity in the CEREP panel with off-targets with >50% inhibition are TACR1, HTR2B and ACHE.GNE-2256 is potent in the NanoBRET assay (IC50 = 3.3 nM), the IL-6 human whole blood assay (IC50=190 nM) and the IFNα human whole blood assay (IC50=290 nM). |
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| Molecular Formula | C24H27FN6O4 |
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| Molecular Weight | 482.516 |