BAY-850
Modify Date: 2025-09-19 20:24:28
BAY-850 structure
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Common Name | BAY-850 | ||
|---|---|---|---|---|
| CAS Number | 2099142-76-2 | Molecular Weight | 654.24 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C38H44ClN5O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BAY-850BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM. |
| Name | BAY-850 |
|---|
| Description | BAY-850 is a potent and isoform selective ATPase family AAA domain-containing protein 2 (ATAD2) inhibitor, with an IC50 of 166 nM. |
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| Related Catalog | |
| Target |
ATAD2[1]. |
| In Vitro | BAY-850 competes with the binding of a mono-acetylated Histone H4 N-terminal peptide to ATAD2 BD with an IC50 of 166 nM measured in TR-FRET assay. BAY-850 displaces the tetra-acetylated peptide with an IC50 of 157 nM and a KD of 115 nM respectively. The unprecedented isoform selectivity of BAY-850 suggests a different mode of action to those exhibited by canonical BD inhibitors[1]. |
| References |
| Molecular Formula | C38H44ClN5O3 |
|---|---|
| Molecular Weight | 654.24 |
| InChIKey | BSISGUIVBKDTQO-JLXKDNNHSA-N |
| SMILES | COc1cc(Cl)c(C(=O)NC(CNC2CCC(N)CC2)Cc2ccc(C#N)cc2)cc1-c1ccc(CNC(C)c2ccc(C)cc2)o1 |