KRpep-2d

Modify Date: 2025-08-25 17:58:20

KRpep-2d Structure
KRpep-2d structure
Common Name KRpep-2d
CAS Number 2098181-84-9 Molecular Weight 2560.02
Density N/A Boiling Point N/A
Molecular Formula C109H183N43O25S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of KRpep-2d


KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1].

 Names

Name KRpep-2d

 KRpep-2d Biological Activity

Description KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1].
Related Catalog
Target

K-RAS

In Vitro KRpep-2d has cyclic structure with importance for K-Ras inhibitory activity. Leu77 , Ile9 and Asp12 are critical amino acid residues for the K-Ras inhibitory activity of KRpep-2d[1]. KRpep-2d (10-30 μM) has inhibitory activity of A427 cells with the proliferation rates of 68.3% (10 μM) and 48.3% (10 μM)[1].
References

[1]. Niida A, et al. Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761.

 Chemical & Physical Properties

Molecular Formula C109H183N43O25S2
Molecular Weight 2560.02
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