NVP-MELK8a hydrochloride
Modify Date: 2025-09-10 18:35:04
NVP-MELK8a hydrochloride structure
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Common Name | NVP-MELK8a hydrochloride | ||
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| CAS Number | 2096992-20-8 | Molecular Weight | 469.02212 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H33ClN6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NVP-MELK8a hydrochlorideNVP-MELK8a hydrochloride (MELK8a hydrochloride) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM; exhibits high selectivity with only 7 off-target kinases inhibited >85% against 456 kinases at 1 uM, Flt3 (IC50=0.18 uM), Haspin (IC50=0.19 uM), PDGFRα (IC50=0.42 uM); exhibits growth inhibition of MDA-MD-468 cells with IC50 of 0.11 uM, and increases cells harboring 4N DNA content. |
| Name | NVP-MELK8a hydrochloride |
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| Description | NVP-MELK8a hydrochloride (MELK8a hydrochloride) is a novel potent, and selective MELK inhibitor with IC50 of 2 nM; exhibits high selectivity with only 7 off-target kinases inhibited >85% against 456 kinases at 1 uM, Flt3 (IC50=0.18 uM), Haspin (IC50=0.19 uM), PDGFRα (IC50=0.42 uM); exhibits growth inhibition of MDA-MD-468 cells with IC50 of 0.11 uM, and increases cells harboring 4N DNA content. |
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| References | References 1. Touré BB, et al. J Med Chem. 2016 May 26;59(10):4711-23. 2. Huang HT, et al. Elife. 2017 Sep 19;6. pii: e26693. View Related Products by Target MELK |
| Molecular Formula | C25H33ClN6O |
|---|---|
| Molecular Weight | 469.02212 |
| InChIKey | AFGMSRRNYDSRPT-UHFFFAOYSA-N |
| SMILES | CN1CCN(c2ccc(-n3cc(-c4ccncc4OCC4CCNCC4)cn3)cc2)CC1.Cl |
| Storage condition | 2-8℃ |