4-(BENZO[D]OXAZOL-2-YL)ANILINE

Modify Date: 2024-01-08 12:34:25

4-(BENZO[D]OXAZOL-2-YL)ANILINE Structure
4-(BENZO[D]OXAZOL-2-YL)ANILINE structure
Common Name 4-(BENZO[D]OXAZOL-2-YL)ANILINE
CAS Number 20934-81-0 Molecular Weight 210.23100
Density 1.257g/cm3 Boiling Point 361.4ºC at 760mmHg
Molecular Formula C13H10N2O Melting Point N/A
MSDS N/A Flash Point 172.4ºC

 Use of 4-(BENZO[D]OXAZOL-2-YL)ANILINE


4-(Benzo[d]oxazol-2-yl)aniline is a potent antitumor agent. 4-(Benzo[d]oxazol-2-yl)aniline has inhibitory activity against mammary carcinoma cell lines[1].

 Names

Name 4-(1,3-benzoxazol-2-yl)aniline
Synonym More Synonyms

 4-(BENZO[D]OXAZOL-2-YL)ANILINE Biological Activity

Description 4-(Benzo[d]oxazol-2-yl)aniline is a potent antitumor agent. 4-(Benzo[d]oxazol-2-yl)aniline has inhibitory activity against mammary carcinoma cell lines[1].
Related Catalog
In Vitro 4-(Benzo[d]oxazol-2-yl)aniline (compound 5b) (0-100 μM; 7 days for MCF-7 and 10 days for MDA 468) has inhibitory activity against MCF-7 and MDA 468 mammary carcinoma cell lines[1]. Cell Proliferation Assay[1] Cell Line: MCF-7 and MDA 468 Concentration: 0-100 μM Incubation Time: 7 days for MCF-7 and 10 days for MDA 468 Result: Exhibited inhibitory activity against MCF-7 (IC50>0.01-0.1 μM) and MDA 468 (IC50>0.1-1 μM).
References

[1]. Shi DF, et al. Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. J Med Chem. 1996 Aug 16;39(17):3375-84.

 Chemical & Physical Properties

Density 1.257g/cm3
Boiling Point 361.4ºC at 760mmHg
Molecular Formula C13H10N2O
Molecular Weight 210.23100
Flash Point 172.4ºC
Exact Mass 210.07900
PSA 52.05000
LogP 3.65820
Vapour Pressure 2.08E-05mmHg at 25°C
Index of Refraction 1.682

 Safety Information

Hazard Codes Xi
HS Code 2934999090

 Synthetic Route

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

4-Benzoxazol-2-ylphenylamine
4-Benzooxazol-2-yl-phenylamine