Vebicorvir
Modify Date: 2024-01-14 09:03:58
Vebicorvir structure
|
Common Name | Vebicorvir | ||
|---|---|---|---|---|
| CAS Number | 2090064-66-5 | Molecular Weight | 467.44 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 566.3±50.0 °C at 760 mmHg | |
| Molecular Formula | C19H12F3N3O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 296.3±30.1 °C | |
Use of VebicorvirVebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. Vebicorvir (ABI-H0731) suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM[1]. |
| Name | 11-Oxo-N-{[2-(trifluoromethyl)-1,3-thiazol-5-yl]methyl}-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide 5,5-dioxide |
|---|---|
| Synonym | More Synonyms |
| Description | Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. Vebicorvir (ABI-H0731) suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM[1]. |
|---|---|
| Related Catalog | |
| In Vitro | Vebicorvir (ABI-H0731) demonstrates inhibition of pgRNA, HBeAg, and HBsAg production, with EC50s of 2.68 μM, 4.95 μM, and 7.30 μM, respectively[1]. Vebicorvir (ABI-H0731) is an inhibitor of pgRNA encapsidation and rcDNA synthesis[1]. |
| In Vivo | After i.v. administration, the drug rapidly distributes and decayes in a biphasic manner in all species tested. Plasma clearance values of ABI-H0731 were 8.05, 10.1, 14.7, and 4.86 ml/min/kg, representing 9, 16, 47, and 11% of liver blood flow, in mouse, rat, dog, and monkey, respectively[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 566.3±50.0 °C at 760 mmHg |
| Molecular Formula | C19H12F3N3O4S2 |
| Molecular Weight | 467.44 |
| Flash Point | 296.3±30.1 °C |
| Exact Mass | 467.022125 |
| LogP | 2.02 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.619 |
| 11-Oxo-N-{[2-(trifluoromethyl)-1,3-thiazol-5-yl]methyl}-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide 5,5-dioxide |
| Dibenzo[b,f][1,4]thiazepine-8-carboxamide, 10,11-dihydro-11-oxo-N-[[2-(trifluoromethyl)-5-thiazolyl]methyl]-, 5,5-dioxide |