Vebicorvir

Names

[ CAS No. ]:
2090064-66-5

[ Name ]:
Vebicorvir

[Synonym ]:
11-Oxo-N-{[2-(trifluoromethyl)-1,3-thiazol-5-yl]methyl}-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide 5,5-dioxide
Dibenzo[b,f][1,4]thiazepine-8-carboxamide, 10,11-dihydro-11-oxo-N-[[2-(trifluoromethyl)-5-thiazolyl]methyl]-, 5,5-dioxide

Biological Activity

[Description]:

Vebicorvir (ABI-H0731) is a first-generation hepatitis B virus (HBV) core protein inhibitor. Vebicorvir (ABI-H0731) suppresses covalently closed circular DNA (cccDNA) formation in two de novo infection models with EC50s from 1.84 μM to 7.3 μM[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> HBV

Research Areas >> Inflammation/Immunology

[In Vitro]

Vebicorvir (ABI-H0731) demonstrates inhibition of pgRNA, HBeAg, and HBsAg production, with EC50s of 2.68 μM, 4.95 μM, and 7.30 μM, respectively[1]. Vebicorvir (ABI-H0731) is an inhibitor of pgRNA encapsidation and rcDNA synthesis[1].

[In Vivo]

After i.v. administration, the drug rapidly distributes and decayes in a biphasic manner in all species tested. Plasma clearance values of ABI-H0731 were 8.05, 10.1, 14.7, and 4.86 ml/min/kg, representing 9, 16, 47, and 11% of liver blood flow, in mouse, rat, dog, and monkey, respectively[1].

[References]

[1]. Qi Huang, et al. Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01463-20.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
566.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₉H₁₂F₃N₃O₄S₂

[ Molecular Weight ]:
467.44

[ Flash Point ]:
296.3±30.1 °C

[ Exact Mass ]:
467.022125

[ LogP ]:
2.02

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.619

Related Compounds

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