MT1

Modify Date: 2024-01-03 12:00:18

MT1 Structure
MT1 structure
Common Name MT1
CAS Number 2060573-82-0 Molecular Weight 1134.20
Density N/A Boiling Point N/A
Molecular Formula C54H66Cl2N10O9S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MT1


MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1)[1].

 Names

Name MT1

 MT1 Biological Activity

Description MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1)[1].
Related Catalog
In Vitro MT1 (100 nM, 24 h) significantly induces apoptosis via caspase-3 and PARP in MV4;11 cells[1]. Western Blot Analysis[1] Cell Line: MV4;11 cells[1]. Concentration: 100 nM. Incubation Time: 24 h. Result: Significant apoptosis was observed by caspase-3 and PARP cleavage after treatment.
In Vivo MT1 (44.2 and 22.1 µmol/kg, ip daily, for 14 days) significantly delayed leukemia progression in mice (Mus musculus) compared to JQ1[1]. MT1 exhibits terminal t1/2 of 2.70 h in mice[1]. Animal Model: Leukemia xenograft models[1]. Dosage: 44.2 and 22.1 µmol/kg. Administration: Intraperitoneally for 14 subsequent days. Result: Significantly reduced leukemic burden over the course of the study compared to either vehicle or JQ1.
References

[1]. Minoru Tanaka, et al. Design and characterization of bivalent BET inhibitors. Nat Chem Biol. 2016 Dec;12(12):1089-1096.

 Chemical & Physical Properties

Molecular Formula C54H66Cl2N10O9S2
Molecular Weight 1134.20
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