2060573-82-0
2060573-82-0 structure
- Name: MT1
- Chemical Name: MT1
- CAS Number: 2060573-82-0
- Molecular Formula: C54H66Cl2N10O9S2
- Molecular Weight: 1134.20
- Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
- Create Date: 2021-01-09 19:40:20
- Modify Date: 2024-01-03 12:00:18
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MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1)[1].
| Name | MT1 |
|---|
| Description | MT1 is a bivalent chemical probe of BET bromodomains, with an IC50 of 0.789 nM for BRD4(1)[1]. |
|---|---|
| Related Catalog | |
| In Vitro | MT1 (100 nM, 24 h) significantly induces apoptosis via caspase-3 and PARP in MV4;11 cells[1]. Western Blot Analysis[1] Cell Line: MV4;11 cells[1]. Concentration: 100 nM. Incubation Time: 24 h. Result: Significant apoptosis was observed by caspase-3 and PARP cleavage after treatment. |
| In Vivo | MT1 (44.2 and 22.1 µmol/kg, ip daily, for 14 days) significantly delayed leukemia progression in mice (Mus musculus) compared to JQ1[1]. MT1 exhibits terminal t1/2 of 2.70 h in mice[1]. Animal Model: Leukemia xenograft models[1]. Dosage: 44.2 and 22.1 µmol/kg. Administration: Intraperitoneally for 14 subsequent days. Result: Significantly reduced leukemic burden over the course of the study compared to either vehicle or JQ1. |
| References |
| Molecular Formula | C54H66Cl2N10O9S2 |
|---|---|
| Molecular Weight | 1134.20 |