BRD5648
Modify Date: 2024-01-16 08:52:46
BRD5648 structure
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Common Name | BRD5648 | ||
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| CAS Number | 2056261-42-6 | Molecular Weight | 321.42 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H23N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BRD5648BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2]. |
| Name | BRD5648 |
|---|
| Description | BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705. BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor with an IC50 of 66 nM and a Kd of 4.8 μM. BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50 of 515 nM). BRD0705 can be used for acute myeloid leukemia (AML)[1][2]. |
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| Related Catalog | |
| In Vitro | BRD5648, the inactive enantiomer of BRD0705, does not induce changes in enzyme phosphorylation or total β-catenin protein stabilization[1]. |
| References |
| Molecular Formula | C20H23N3O |
|---|---|
| Molecular Weight | 321.42 |