GLPG2451

Modify Date: 2025-08-25 18:54:44

GLPG2451 structure	Common Name	GLPG2451
	CAS Number	2055015-61-5	Molecular Weight	419.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₆F₃N₃O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of GLPG2451

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1].

Name	GLPG2451

Description	GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR Research Areas >> Inflammation/Immunology
Target	Cystic fibrosis transmembrane conductance regulator[1]
In Vitro	GLPG2451 has an EC50 value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells[1].
References	[1]. Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221.

Molecular Formula	C₁₆H₁₆F₃N₃O₅S
Molecular Weight	419.38

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: GLPG2451
Price: Check
Purity: 98.0%
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Contact: Yang
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GLPG2451

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GLPG2451 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.