GLPG2451

Names

[ CAS No. ]:
2055015-61-5

[ Name ]:
GLPG2451

Biological Activity

[Description]:

GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> CFTR

Research Areas >> Inflammation/Immunology

[Target]

Cystic fibrosis transmembrane conductance regulator[1]

[In Vitro]

GLPG2451 has an EC50 value of 675 nM and an efficacy level of 147% of that of VX770 in G551D/F508del cells[1].

[References]

[1]. Gees M, et al. Identification and Characterization of Novel CFTR Potentiators. Front Pharmacol. 2018 Oct 26;9:1221.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₆F₃N₃O₅S

[ Molecular Weight ]:
419.38

Related Compounds

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