BTM-3528
Modify Date: 2025-11-27 09:25:30
BTM-3528 structure
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Common Name | BTM-3528 | ||
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| CAS Number | 2054998-45-5 | Molecular Weight | 521.55 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H19F4N3O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BTM-3528BTM-3528 is an activator of the mitochondrial protease OMA1 and mediates excessive activation of the mitochondrial integrated stress response (ISR). BTM-3528 stimulates OMA1-dependent DELE1 and OPA1 cleavage and mitochondrial fragmentation. BTM-3528 activates eIF2α kinase HRI, inducing cell growth arrest and apoptosis. BTM-3528 has anticancer activity against multiple DLBCL cell lines and has in vivo inhibitory potency in a mouse model xenografted with human DLBCL SU-DHL-10 cells[1]. |
| Name | BTM-3528 |
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| Description | BTM-3528 is an activator of the mitochondrial protease OMA1 and mediates excessive activation of the mitochondrial integrated stress response (ISR). BTM-3528 stimulates OMA1-dependent DELE1 and OPA1 cleavage and mitochondrial fragmentation. BTM-3528 activates eIF2α kinase HRI, inducing cell growth arrest and apoptosis. BTM-3528 has anticancer activity against multiple DLBCL cell lines and has in vivo inhibitory potency in a mouse model xenografted with human DLBCL SU-DHL-10 cells[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C24H19F4N3O2S2 |
|---|---|
| Molecular Weight | 521.55 |
| InChIKey | CSKLESTWCMVVHO-UHFFFAOYSA-N |
| SMILES | Cc1nn(-c2nc(-c3ccc(C(F)(F)F)cc3)c(SC(C)C)s2)c(C(=O)O)c1-c1cccc(F)c1 |