(S)-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride

Modify Date: 2024-01-04 13:58:55

(S)-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride Structure
(S)-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride structure
Common Name (S)-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride
CAS Number 20445-33-4 Molecular Weight 252.61800
Density 1.35 g/mL at 25 °C(lit.) Boiling Point 213-214 °C(lit.)
Molecular Formula C10H8ClF3O2 Melting Point N/A
MSDS Chinese USA Flash Point 194 °F
Symbol GHS05
GHS05
Signal Word Danger

 Names

Name (2S)-3,3,3-trifluoro-2-methoxy-2-phenylpropanoyl chloride
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.35 g/mL at 25 °C(lit.)
Boiling Point 213-214 °C(lit.)
Molecular Formula C10H8ClF3O2
Molecular Weight 252.61800
Flash Point 194 °F
Exact Mass 252.01600
PSA 26.30000
LogP 2.85600
Vapour Pressure 0.164mmHg at 25°C
Index of Refraction n20/D 1.47(lit.)
Storage condition −20°C

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes C
Risk Phrases R34:Causes burns.
Safety Phrases S26-S36/37/39-S45-S27
RIDADR UN 3265 8/PG 2
WGK Germany 3
Packaging Group II
Hazard Class 8
HS Code 2918990090

 Synthetic Route

~99%

(S)-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride Structure

(S)-(+)-alpha-m...

CAS#:20445-33-4

Literature: Mi, Xianwei; Wang, Yan; Zhu, Lili; Hong, Ran; Wang, Renxiao Synthesis, 2012 , vol. 44, # 22 art. no. SS2012Z0663FA, p. 3432 - 3440,9 Title/Abstract Full Text Show Details Mi, Xianwei; Wang, Yan; Zhu, Lili; Wang, Renxiao; Hong, Ran Synthesis (Germany), 2012 , vol. 44, # 22 art. no. SS-2012-Z0663-FA, p. 3432 - 3440

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(S)-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride Structure

(S)-(+)-alpha-m...

CAS#:20445-33-4

Literature: Tetrahedron Letters, , vol. 32, # 49 p. 7165 - 7166

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(S)-(+)-alpha-methoxy-alpha-trifluoromethylphenylacetyl chloride Structure

(S)-(+)-alpha-m...

CAS#:20445-33-4

Literature: Chemical and Pharmaceutical Bulletin, , vol. 40, # 9 p. 2469 - 2472

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles6

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Six new compounds with polyketide decalin ring, peaurantiogriseols A-F (1-6), along with two known compounds, aspermytin A (7), 1-propanone,3-hydroxy-1- (1,2,4a,5,6,7,8,8a-octahydro-2,5-dihydroxy-1,2,...

High-performance liquid chromatographic resolution of enantiomers of 1-phenyl-2-aminopropanes (amphetamines) with four chiral reagents.

J. Chromatogr. A. 307 , 335, (1984)

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Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons.

Nat. Protoc. 2 , 2451-2458, (2007)

This protocol details the most commonly used nuclear magnetic resonance (NMR)-based method for deducing the configuration of otherwise unknown stereogenic, secondary carbinol (alcohol) centers (R1R2CH...

 Synonyms

(+)-α-Methoxy-α-(trifluoroMethyl)phenylacetyl Chloride
(2S)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride
MFCD00067105
(S)-(+)-Mosher's acid chloride
(S)-(+)-MTPA-Cl
(+)-1-methoxy-1-(trifluoromethyl)phenylacetyl chloride
(+)-MTPA-Cl
(S)-3,3,3-Trifluoro-2-methoxy-2-phenylpropanoyl chloride
(+)-Moshers Acid Chloride
(+)-Mosher's Acid Chloride
Mosher's acid chloride
(+)-Mtpa chloride
(S)-(+)-α-Methoxy-α-t
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