CPUL1
Modify Date: 2024-04-03 13:22:26
CPUL1 structure
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Common Name | CPUL1 | ||
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| CAS Number | 2043660-80-4 | Molecular Weight | 434.28 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H13Cl2N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CPUL1CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective[1]. |
| Name | CPUL1 |
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| Description | CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective[1]. |
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| Related Catalog | |
| In Vitro | CPUL1 (2.5, 5, 10, 20, 40 μM; 48 h) inhibits A549 cell proliferation and (2, 4, 8 μM; 48 h) colony formation[1]. CPUL1 (4, 8 μM; 0, 24, 48 h) inhibits A549 cells migration and (2, 4, 8 μM; 48 h) invasion[1]. CPUL1 hinders EMT (epithelial-mesenchymal transition) progress and affects MAPK pathway in A549 cells[1]. Cell Proliferation Assay[1] Cell Line: A549 cells Concentration: 2.5, 5, 10, 20, 40 μM Incubation Time: 48 h Result: Showed a dose-dependent cytotoxicity, with an IC50 value of 7.61 μM. Cell Viability Assay[1] Cell Line: A549 cells Concentration: 2, 4, 8 μM Incubation Time: 48 h Result: Significantly abolished the capacity of A5459 cells to form colonies at the dose-dependent concentration. Cell Migration Assay [1] Cell Line: A549 cells Concentration: 4, 8 μM Incubation Time: 0, 24, 48 h Result: Inhibited the migration of A549 cells in a dose- and time-dependent manner. |
| Molecular Formula | C22H13Cl2N5O |
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| Molecular Weight | 434.28 |