ZM223
Modify Date: 2025-08-25 10:36:27
ZM223 structure
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Common Name | ZM223 | ||
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| CAS Number | 2031177-48-5 | Molecular Weight | 502.53 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H17F3N4O2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ZM223ZM223 is a novel non-sulfamide NEDD8 activating enzyme inhibitor that inhibits HCT116 colon cancer cells with an IC50 value of 100 nM. |
| Name | ZM223 |
|---|
| Description | ZM223 is a novel non-sulfamide NEDD8 activating enzyme inhibitor that inhibits HCT116 colon cancer cells with an IC50 value of 100 nM. |
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| Related Catalog | |
| Target |
IC50: 100 nM (HCT116), 122 nM (U-2OS)[1] |
| In Vitro | ZM223 exhibits excellent antitumor activities against both HCT116 and U-2OS cells (IC50=100, 122 nM)[1]. Western Blot Analysis[1] Cell Line: HCT-116 cells Concentration: 0.1, 1 μM Incubation Time: 4 hours Result: ZM223 inhibited NEDD8 protein and subsequently elevated UBC12 level[1]. |
| References |
| Molecular Formula | C23H17F3N4O2S2 |
|---|---|
| Molecular Weight | 502.53 |
| InChIKey | XPPKZMFJCSEUSX-UHFFFAOYSA-N |
| SMILES | Nc1ccc(SCC(=O)Nc2ccc3nc(NC(=O)c4ccc(C(F)(F)F)cc4)sc3c2)cc1 |
| Storage condition | 2-8℃ |