ZM223

Names

[ CAS No. ]:
2031177-48-5

[ Name ]:
ZM223

Biological Activity

[Description]:

ZM223 is a novel non-sulfamide NEDD8 activating enzyme inhibitor that inhibits HCT116 colon cancer cells with an IC50 value of 100 nM.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> NEDD8-activating Enzyme

[Target]

IC50: 100 nM (HCT116), 122 nM (U-2OS)[1]

[In Vitro]

ZM223 exhibits excellent antitumor activities against both HCT116 and U-2OS cells (IC50=100, 122 nM)[1]. Western Blot Analysis[1] Cell Line: HCT-116 cells Concentration: 0.1, 1 μM Incubation Time: 4 hours Result: ZM223 inhibited NEDD8 protein and subsequently elevated UBC12 level[1].

[References]

[1]. Ma H, et al. Discovery of benzothiazole derivatives as novel non-sulfamide NEDD8 activating enzyme inhibitors by target-based virtual screening. Eur J Med Chem. 2017 Jun 16;133:174-183.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₇F₃N₄O₂S₂

[ Molecular Weight ]:
502.53

[ Storage condition ]:
2-8℃

Related Compounds

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