Seletracetam lithium bromide
Modify Date: 2024-01-08 11:10:05
Seletracetam lithium bromide structure
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Common Name | Seletracetam lithium bromide | ||
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| CAS Number | 2024584-38-9 | Molecular Weight | 275.74 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C10H14F2N2O2.1/2BrLi | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Seletracetam lithium bromideSeletracetam (Ucb 44212) lithium bromide, an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy[1][2][3]. |
| Name | Seletracetam lithium bromide |
|---|
| Description | Seletracetam (Ucb 44212) lithium bromide, an analog of the antiepileptic agent Levetiracetam, is a SV2A modulator for the research of epilepsy[1][2][3]. |
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| Related Catalog | |
| Target |
IC50: SV2A[1] |
| In Vitro | Seletracetam displays one-log-unit higher affinity (pKi=7.1) than Levetiracetam (6.1) to the LEV-binding site[2]. Seletracetam lithium bromide inhibits high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro[2]. Seletracetam (1-10 μM) lithium bromide reduces both the amplitude and repetitive firing of population spikes induced by a high K+/low Ca2+ concentration fluid (HKLCF) in rat hippocampal slices[3]. |
| In Vivo | Seletracetam (intraperitoneal injection) lithium bromide displays potent protection against secondary generalised motor seizures in fully corneally-kindled mice (ED50 0.31 mg/kg). In audiogenic seizure susceptible mice, Seletracetam (i.p) protects against clonic convulsion expression with an ED50 of 0.17 mg/kg[3]. Seletracetam (0.0074 mg/kg to 74 mg/kg; intraperitoneal injection) lithium bromide increases the generalized seizure threshold current and decreases the duration of the after-discharge and the seizure severity observed at the after-discharge threshold current, and generally has a much more potent effect than previously observed for Levetiracetam[3]. Animal Model: Female Wistar rats (200-220 g) (Amygdala-kindled rats)[3] Dosage: 0.0074,7.4, 74 mg/kg Administration: Intraperitoneal injection; 60 min before seizure threshold determination Result: Markedly increased the generalized seizure threshold at all doses tested, with increases of 190% (0.0074 mg/kg), 302% (0.074 mg/kg), 429% (0.74 mg/kg), 433% (7.4 mg/kg) and 679% (74 mg/kg). |
| References |
| Molecular Formula | C10H14F2N2O2.1/2BrLi |
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| Molecular Weight | 275.74 |