Tubulin polymerization-IN-36
Modify Date: 2024-03-08 18:31:13
Tubulin polymerization-IN-36 structure
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Common Name | Tubulin polymerization-IN-36 | ||
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| CAS Number | 2011784-91-9 | Molecular Weight | 310.35 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H18N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tubulin polymerization-IN-36Tubulin polymerization-IN-36 is a tubulin polymerization inhibitor (IC50: 2.8 μΜ). Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-36 can be used in the research of cancers, such as lymphomas[1]. |
| Name | Tubulin polymerization-IN-36 |
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| Description | Tubulin polymerization-IN-36 is a tubulin polymerization inhibitor (IC50: 2.8 μΜ). Tubulin polymerization-IN-36 binds to the colchicine site of tubulin and inhibits colchicine binding. Tubulin polymerization-IN-36 can be used in the research of cancers, such as lymphomas[1]. |
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| Related Catalog | |
| Target |
Tubulin polymerization[1] |
| In Vitro | Tubulin polymerization-IN-36 (compound 2e, 1 μΜ, 72 h) inhibits proliferation of lymphoma cells below 50%[1]. Tubulin polymerization-IN-36 (50 and 500 nM, 24-72 h) induces cell apoptosis and arrests cell in G2/M phase in VL51 and MINO cells[1]. Tubulin polymerization-IN-36 (5 μΜ) inhibits colchicine binding to tubulin by 88%[1]. Tubulin polymerization-IN-36 shows cytotoxicity against MCF-7 cells (IC50: 0.29 μΜ)[1]. Cell Proliferation Assay[1] Cell Line: VL51, MINO, HBL1, SU-DHL-10 cells. Concentration: 0-10 μΜ Incubation Time: 72 h Result: Inhibited cell proliferation to 38%, 0.8%, 7.1%, 30.5% at 1 μΜ, respectively. IC50s: 0.04, 0.02, 0.02, 0.03 μΜ, respectively. Cell Cycle Analysis[1] Cell Line: VL51 and MINO cells Concentration: 50 and 500 nM Incubation Time: 24, 48 and 72 h Result: Arrested cell in G2/M phase. |
| References |
| Molecular Formula | C18H18N2O3 |
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| Molecular Weight | 310.35 |